Search results for "miRNA Genes"

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Assessing the impact of copy number variants on miRNA genes in autism by Monte Carlo simulation.

2014

Autism Spectrum Disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies have investigated the role of de novo Copy Number Variants (CNVs) and microRNAs as important but distinct etiological factors in ASD. We developed a novel computational procedure to assess the potential pathogenic role of microRNA genes overlapping de novo CNVs in ASD patients. Here we show that for chromosomes # 1, 2 and 22 the actual number of miRNA loci affected by de novo CNVs in patients was found significantly higher than that estimated by Monte Carlo simulation of random CNV events. Out of 24 miRNA genes over-represented in CNVs from these three chromosomes only …

Clinical PathologyDNA Copy Number Variationsendocrine system diseasesChromosomes Human Pair 22ScienceGene regulatory networkGenomicsDevelopmental and Pediatric NeurologyBiologyPathology and Laboratory MedicinePediatricsGenomeMolecular GeneticsmiRNA Genes Monte Carlo Simulation AutismDiagnostic Medicinemental disordersGeneticsMedicine and Health SciencesmedicineHumansComputer SimulationGene Regulatory NetworksCopy-number variationAutistic DisorderGeneGeneticsMultidisciplinaryGenome HumanQRBiology and Life SciencesComputational BiologyGenomicsGenome Analysismedicine.diseaseSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)MicroRNAsNeurologyChromosomes Human Pair 1Genetic LociAutism spectrum disorderChromosomes Human Pair 2AutismMedicineStructural GenomicsHuman genomeMonte Carlo MethodResearch ArticlePLoS ONE
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